Regression Models as a Tool in Medical Research

A web based distance learning course

Aim: The participants should become familiar with the basic concepts and techniques in using regression models in medical research. They should be enabled to perform analyses of their own data, and to interpret, communicate and publish the results. They should also understand the basic potentials and limitations in using regression models and get some inspiration for a more effective and a more understandable use of regression models.

Target group: Postgraduate students and young researchers from the health sciences and related fields who want to work with regression models in their own research or wish to understand regression model based analyses found in the literature.

Topics covered:

All topics will be illustrated by examples from various fields of medical research like prognostic studies, epidemiological risk factor studies, experimental studies, diagnostic studies and observational studies.

Prerequisites: Only some basic knowledge of statistical terms like mean, p-value and confidence interval is required. The participants should have access to the Internet.

Registration fee: The registration fee depends on the source of the financial support for the participant:

self paying academic institution / non-profit organization commercial sector
including one year license of Stata 450 EURO 650 EURO 1000 EURO
without Stata license 400 EURO 600 EURO 900 EURO

If organizations want to send 2 or more participants to the course, we offer reduced fees. Please contact us at info@isqr.uni-freiburg.de.

Registration: Starting November 15, 2011, you can register for the course at http://www.isqr.intercongress.de. You can pay directly with a credit card, or you can transfer your registration fee to a bank account.

Stipends: A few stipends are available for participants who cannot afford the registration fee. Please fill out the application form and send it to stipend@isqr.uni-freiburg.de. For further questions, please do not hesitate to contact us.

Practicalities: The course is offered as a web based distance learning course over a period of 16 weeks. The participants are expected to download and read about 25-35 pages of teaching material (pdf-files) each week. Examples from the teaching material can be found here. The teaching material covers an introduction into the concepts and methods as well as instructions how to apply the methods using the statistical package Stata. Each week there will be practical exercises, with solutions provided one week later. There will be a discussion list allowing communication among the participants and with the teaching staff. Any question to the teaching staff will be answered within 24 hours.

Use of Stata: A one year license of Stata 12 is included in the registration fee. Stata is available for Windows, Unix and Mac. For further details visit the Stata home page.
Participants unfamiliar with Stata will get a short introduction prior to the course. The examples and exercises of the course require access to Stata 10, 11 or 12. The Intercooled version of Stata is sufficient.

Course certificate: A course certificate is given to all participants, who participated in a multiple choice test and delivered a final written exercise.

Course credits: 8 ECTS

Teaching staff:
Werner Vach and Primrose Beryl, Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University of Freiburg

Course administration:
Per Berg and Monika Richards, International School of Quantitative Research, University of Freiburg
email: info@isqr.uni-freiburg.de

Important dates
February 2, 2012 Final date for registration of participants who need an introduction to Stata or a Stata license
February 16, 2012 Start of one-week introduction to Stata
February 21, 2012 Final date for registration of participants who have a Stata license
February 23, 2012 Start of teaching period
June 28, 2012 End of teaching period (Discussion list will be served until July 5)
June 28, 2012 Multiple choice test and homework for course certificate will be available
August 23, 2012 Final deadline for delivery of written exercise

Course schedule: Each teaching week starts on a Thursday. The material for each week will be available already one the preceding Tuesday. The discussion of the contents of each teaching week on the discussion list should be limited to the teaching week and the following two weeks.

Start date Unit Topics
February 23 Week 1 Why using regression models?
An introductory example
Adjusted effects
March 1 Week 2 Inference for the classical multiple regression model
Logistic regression
March 8 Week 3 Inference for the logistic regression model
Categorical covariates
March 15 Week 4 Handling ordered categories: A first lesson in regression modeling strategies
The Cox proportional hazard model
Common pitfalls in using regression models
March 22 Week 5 Some useful technicalities
Comparing regression coefficients
March 29 Week 6 Power and sample size I
April 5 Easter break
April 12 Week 7 Power and sample size II
The selection of the sample
April 19 Week 8 The selection of variables for a regression analysis
April 26 Week 9 Modelling non-linear effects I
May 3 Week 10 Modelling non-linear effects II
Transformation of covariates
May 10 Week 11 Effect modifications and interactions
May 17 Week 12 Applying regression models to clustered data
Applying regression models to longitudinal data
May 24 Whitsun break
May 31 Week 13 Risk scores
June 7 Week 14 Construction of predictors
Evaluating the predictive performance
June 14 Week 15 The impact of measurement error on a regression analysis
The impact of incomplete data on a regression analysis
Alternatives to regression modeling
June 21 Week 16 Specific regression models and specific usages of regression models
The goodness of a model
Regression modeling strategies

Evaluation of previous courses: Some information about the evaluation of a previous version of this course can be found here.